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Cat. No. | Product Name | Target | Signaling Pathways |
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T78044 |
α-Methyl-DL-aspartic acid
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α-Methyl-DL-aspartic acid为特异性抑制剂,针对精氨酸琥珀酸合成酶(ASS),亦作用于1-瓜氨酸向1-精氨酸循环的限速酶。 | |||
T81922 |
LM2I
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LM2I是一种多杀菌素(SPA)衍生物,兼具精氨酸琥珀酸合成酶(ASS1)激活剂和针对ASS1的直接作用的肿瘤抑制剂功能。在7种结直肠癌细胞系和结直肠癌异种移植肿瘤中,LM2I展现出明显的抗增殖活性,并且通过EGFR途径阻断结直肠癌细胞增长。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00732 |
ASS1 Protein, Human, Recombinant (His)
Citrulline--Aspartate Ligase,Argininosuccinate ... |
Human | E. coli |
Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullin... | |||
TMPH-02527 |
ASS1 Protein, Mouse, Recombinant (His & Myc)
Ass,Citrulline--aspartate ligase,Ass1,Argininosuccinate<... |
Mouse | E. coli |
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. ASS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 5... | |||
TMPY-03172 |
Argininosuccinate lyase Protein, Human, Recombinant (His & GST)
ASAL,argininosuccinate lyase,ASL |
Human | Baculovirus Insect Cells |
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate ... |